Fig. 2.

TRPV4 affected the behavioral performances of PD mice. After infused with 0.5 μl AAV-TRPV4 shRNAi or 0.3 μl AAV-TRPV4 bilaterally into the SN for 21 days and administrated with MPTP at 30 mg/kg/day for 7 days, mice were subjected to movement behavioral tests, including the pole test and rotarod test. A Knockdown of TRPV4 restored the T-tune time of PD mice (n = 12). B Upregulation of TRPV4 further prolonged the T-tune time of PD mice (n = 12). C Knockdown of TRPV4 restored the T-descend time of PD mice (n = 12). D Upregulation of TRPV4 further prolonged the T-descend time of PD mice (n = 12). E Knockdown of TRPV4 restored the retention time of PD mice (n = 12). F Upregulation of TRPV4 further shortened the retention time of PD mice (n = 12). For each condition, data were collected from three trials for each mouse. All data are presented as mean ± SEM. Significant differences: *P < 0.05, **P < 0.01, ***P < 0.001