Fig. 7.

mmu‐miR‐30a‐3p overexpression suppresses Runx2 and Hmgb1 up‐regulation in a mouse model of allergic airway inflammation. a The 3′‐UTR of Runx2 contains the region matching the seed sequence of mmu‐miR‐30a‐3p. b, c The transcript levels of Runx2 (b) and Hmgb1 (c) in mouse lungs were determined by quantitative PCR. The transcript levels were expressed as log2 transformed and relative to the mean of control group. d The protein levels of Hmgb1 in BALF were determined by ELISA. n = 7–10 mice per group. Data are mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001 (one-way ANOVA followed by Tukey’s multiple comparison test). e A model of epithelial microRNA-30a-3p targeting RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma