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. 2022 Jan 29;20:49. doi: 10.1186/s12967-022-03249-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — The therapy effect of epigenetic drugs on HCC cells progression. A The impact of decitabine and CPI-455 on the proliferation of HCC cells was assessed by CCK8 assay respectively. B Decitabine increased the growth of already developed subcutaneous tumors. 3 mg/kg decitabine was administrated by intraperitoneal injection at day8, day10 and day12 into C57BL/6 J mice after implantation. C Decitabine decreased mouse body weight. D The overall survival of mice was significantly poor in decitabine treatment group relative to the controls. p is based on log-rank test. E MCM2 and NUP37 expression in tumors from decitabine or PBS group was analyzed by immunoblotting. Values represent the relative MCM2 or NUP37 expression levels compared to GAPDH