Skip to main content
. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Mol Immunol. 2021 Dec 23;142:1–10. doi: 10.1016/j.molimm.2021.12.011

Figure 7. VNN2+ expression on CD14+ GBM monocytes is decreased compared to controls and VNN2 expression inversely correlates with glioma grade.

Figure 7.

A. An in vitro assay shows GBM Mo-MDSC suppress division of human CD8 T cells. B & C) Expression of VNN2 on high-grade glioma CD14+ GBM monocytes is significantly reduced compared to healthy controls (4% vs 38%, p<0.00001; n=10 and n=9 respectively). D) Compared to healthy control Mo-MDSCs, mRNA expression of VNN2 from GBM patients is reduced (0.23 vs 1, p-<0.04; n=4 and n=3 respectively). E) VNN2 expression on CD14+ cells decreases as glioma grade increases. F) Exposure of healthy CD14+ VNN2+ cells to GBM supernatants decreases expression of VNN2 compared to untreated CD14+ VNN2+ cells (63% vs 23%, p<0.04; n=3 and n=4 respectively).