Table 4.
OS from Relapse KM-probability estimates in FL patients with confirmed relapse, stratified by method of relapse detection
| Cohort | Group | N | Events | Censored | 1-Year Survival | 3-Year Survival | 5-Year Survival |
|---|---|---|---|---|---|---|---|
| LEAD | Clinical Detection | 34 | 7 (21%) | 27 (79%) | 100% (NA, NA) | 97.1% (80.9%, 99.6%) | 95.8% (89.1%, 98.4%) |
| Surveillance Detection | 17 | 2 (12%) | 15 (88%) | 100% (NA, NA) | 93.3% (61.3%, 99.0%) | 86.2% (55.0%, 96.4%) | |
| MER | Clinical Detection | 63 | 14 (22%) | 49 (78%) | 100% (NA, NA) | 95.2% (85.7%, 98.4%) | 90.0% (79.0%, 95.4%) |
| Surveillance Detection | 50 | 12 (24%) | 38 (76%) | 100% (NA, NA) | 98.0% (86.6%, 99.7%) | 96.0% (84.8%, 99.0%) | |
| Combined | Clinical Detection | 98 | 21 (21%) | 77 (79%) | 95.7% (88.8%, 98.3%) | 88.5% (79.6%, 93.6%) | 83.4% (72.7%, 90.1%) |
| Surveillance Detection | 68 | 14 (21%) | 54 (79%) | 96.9% (88.1%, 99.2%) | 91.9% (81.5%, 96.6%) | 85.8% (73.4%, 92.7%) |
OS, overall survival, defined as the time from the date of first relapse until the date of death or last known follow-up; clinical detection, defined by patient-reported symptoms at the time of confirmed detection of disease, concerning physical exam findings documented during a clinical visit, or abnormal lab values on prior follow-up; surveillance detection, defined by relapse of disease first suggested on imaging reviewed by a radiologist, as part of a routine surveillance schedule, and later confirmed by other diagnostic means.
Variables are presented as N (%) or mean survival% (95% confidence interval) unless otherwise noted.
Abbreviations: KM, survival probability estimated using the Kaplan-Meir method; N, total number.