Extended Data Fig. 1 |. Anatomical localization of DBS lead placement (P1, P2, P3, P5).

(A,B) Coronal (A) and axial (B) T1-weighted (T1w) MRI in radiographic convention from participants P1, P2, P3, and P5 overlaid with reconstructed DBS lead trajectories. Colored regions indicate anterior commissure (AC), caudate, putamen, and ventral striatum (VS). The MRI slice shown is immediately posterior (A; coronal) or inferior (B; axial) to the most ventral contact. Enlarged coronal slices (corresponding to white box outlines in panel A) showing DBS contact locations in each hemisphere are shown on either side of the full coronal slice. Green spheres indicate sensing contacts, red spheres indicate stimulating contacts, black spheres indicate contacts that were used for neither stimulation nor sensing. In each participant, the tips of the leads were targeted to either the VS or the bed nucleus of the stria terminalis (BNST) (target regions for each participant are included in Table 1). Enlarged slices shown are immediately posterior to the most ventral contact in each hemisphere. Anterior-posterior slice location (y) is referenced to the posterior border of the AC, which is defined as y=0. (D,E) Front (D) and top-down (E) view of the reconstructed cortical surface, subcortical structures, DBS leads, and AC, shown in radiographic convention.