Extended Data Table 1 |. Participant demographics, DBS surgery device and targets, and stimulation and sensing contact information.
MDD: Major Depressive Disorder, PTSD: Post-Traumatic Stress Disorder, GAD: General Anxiety Disorder, TS: Tourette’s Syndrome., ET: Essential Tremor. *Responder = 35% or greater decrease in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) after 12 months of activation compared to presurgical baseline. N/A refers to participants that have not completed study yet.
| Participant: | PI | P2 | P3 | P4 | P5 | |
|---|---|---|---|---|---|---|
| Gender | Male | Female | Female | Male | Female | |
| Age at time of consent | 31 | 39 | 37 | 40 | 31 | |
| Race | White | White | White | White | White | |
| Ethnicity | Not Hispanic/Latino | Hispanic/Latino | Hispanic/Latino | Not Hispanic/Latino | Not Hispanic/Latino | |
| Primary diagnosis | OCD | OCD | OCD | OCD | OCD | |
| Comorbid diagnoses | MDD | PTSD, MDD, GAD | PTSD, MDD, TS | Bipolar Disorder II | MDD | |
| Principal OCD symptoms | Intrusive aggressive/taboo obsessions with checking and repeating rituals | Intrusive aggressive/sexual taboo obsessions with checking and repeating rituals | Intrusive aggressive thoughts, magical thinking, and scrupulosity with checking and repeating rituals | Contamination and scrupulosity obsessions with cleaning and checking rituals | Intrusive aggressive and contamination obsessions with checking and cleaning rituals | |
| Age of OCD onset (years) | 17 | 18 | 12 | 16 | 8 | |
| Responder status | Yes | Yes | Yes | Yes | Yes | |
| Initial Y-BOCS II (Y- BOCS) score | 37 (35) | 39 (34) | 46 (40) | 42 (38) | 47 (37) | |
| Final Y-BOCS II (Y- BOCS) score | 8(6) | 11(9) | 27 (25) | 25 (22) | 26 (23) | |
| DBS Device | PC+S | PC+S | RC+S | RC+S | RC+S | |
| DBS Target Region | L | BNST | BNST | VCVS | VCVS | BNST |
| R | BNST | BNST | VCVS | BNST | BNST | |
| Stimulating Contact | L | 1−/C+ | 2−/C+ | 1−/C+ | 1 −/C+ | 1−/C+ |
| R | 10−/C+ | OFF | 9−/C+ | 9−/C+ | 9−/C+ | |
| Sensing contact | L | 0–2 | 1–3 | 0–2 | 0–2 | 0–2 |
| R | 9–11 | 9–11 | 8–10 | 8–10 | 10–11 | |
| Final DBS Rate | L | 150 Hz | 150 Hz | 150.6 Hz | 150.6 Hz | 150.6 Hz |
| R | 150 Hz | OFF | 150.6 Hz | 150.6 Hz | 150.6 Hz | |
| Final DBS Amplitude | L | 5.0 V | 5.5 V | 6.0 mA | 5.2 mA | 6.0 mA |
| R | 5.0 V | OFF | 5.7 mA | 5.0 mA | 6.0 mA | |
| Final DBS Pulse Width | L | 120 μs | 120 μs | 210 μs | 120 μs | 180 μs |
| R | 120 μs | OFF | 210 μs | 120 μs | 180 μs | |