Table 3.

Downstream effects of variants

Gene	Amino acid change	Type	Affected region/domain & possible effect
EZH2	W15X	deletion	Interaction with DNMT1, DNMT3A and DNMT3B is lost
FLT3	E598DYVDFREYE	insertion	The region important for normal regulation of the kinase activity is lost.
NPM1	L287LCX	insertion	The region required for nucleolar localization is lost
RAD21	G274X	deletion	D->A: Abolishes cleavage by caspase-3 is lost
BCORL1	E1316	deletion	Nuclear localization signal might get lost