Figure 2. A general schematic of the preclinical and clinical studies.
A) Biospecimen collection for the rat studies (N=820, including non-exercised controls) is ongoing and will be completed in Fall 2020. For both the acute (i.e. single bout; n=526) and chronic phases (i.e. training; n=294), six- and eighteen-month old male and female rats are being studied, and both exercise phases include a cohort of non-exercised controls. B) ~2600 healthy individuals will be evaluated physiologically, and biospecimens will be collected to accommodate molecular probing of various tissues before and after acute and chronic endurance or resistance exercise. For the adult cohort, the control participants will rest quietly (i.e., no exercise) during the acute bout with biospecimen collections.
*Assessments include blood profile, body composition, heart health, VO2max and strength.