Table 2.

SPOKE edge statistics

Node type 1	Edge	Node type 2	Count
Disease	ASSOCIATES_DaG	Gene	1 998 072
Gene	PARTICIPATES_GpBP	Biological process	1 480 742
Protein	INTERACTS_PiP	Protein	1 238 535
Compound	BINDS_CbP	Protein	1 098 776
Anatomy	EXPRESSES_AeG	Gene	1 052 814
Gene	REGULATES_GrG	Gene	531 344
Gene	INTERACTS_GiG	Gene	294 328
Gene	PARTICIPATES_GpMF	Molecular function	260 152
Gene	PARTICIPATES_GpCC	Cellular component	226 582
Gene	PARTICIPATES_GpPW	Pathway	221 080
Anatomy	DOWNREGULATES_AdG	Gene	204 480
Anatomy	UPREGULATES_AuG	Gene	195 696
Disease	RESEMBLES_DrD	Disease	128 000
Gene	COVARIES_GcG	Gene	123 380
Compound	CAUSES_CcSE	Side effect	86 400
Disease	LOCALIZES_DlA	Anatomy	79 010
Protein	TRANSLATEDFROM_PtG	Gene	67 332
Compound	TREATS_CtD	Disease	64 872
Pharmacologic class	INCLUDES_PCiC	Compound	62 952
Disease	PRESENTS_DpS	Symptom	47 606
Compound	DOWNREGULATES_CdG	Gene	42 204
Compound	CONTRAINDICATES_CcD	Disease	41 302
Compound	UPREGULATES_CuG	Gene	37512
Anatomy	ISA_AiA	Anatomy	37 304
Anatomy	CONTAINS_AcA	Anatomy	37 304
Disease	ISA_DiD	Disease	22 952
Disease	CONTAINS_DcD	Disease	22 952
Anatomy	PARTOF_ApA	Anatomy	19 502
Disease	UPREGULATES_DuG	Gene	15 462
Disease	DOWNREGULATES_DdG	Gene	15 246
Compound	RESEMBLES_CrC	Compound	12 972
Compound	INTERACTS_CiP	Protein	6390
Compound	PALLIATES_CpD	Disease	780
Compound	AFFECTS_CamG	Gene	718