Maximum likelihood tree based on the WGS sequences of ten SARS-CoV-2 strains in the course of serial passages in vitro. Sequencing was carried out at passages 0, 3, 5, 7 and 10 respectively, and only high-quality sequences were used for further analysis, as shown here in 49 SARS-CoV-2 with 29,896 nucleotide sites each. Numbers at nodes indicate bootstrap support values (only values > 50 are shown). Bootstrap is also given by branch colour.