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Localization of the aa substitutions and insertions developed convergently from two or more strains during serial passage of ten SARS-CoV-2 strains in vitro. All convergently evolved mutations occurred in the regions coding for ORF1a/nsp3 (1); ORF3a (1), E (1), M (1), ORF8 (1) and spike (8). Substitutions marked with “∗∗∗” evolved convergently in all three highly successful strains.
