Table 1.
Resistance Rates of Escherichia coli and Klebsiella pneumoniae to the Common Antibiotics
| Escherichia coli | Klebsiella pneumoniae | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1998–2002 | 2003–2007 | 2008–2012 | 2013–2017 | 1998–2002 | 2003–2007 | 2008–2012 | 2013–2017 | |||||||||
| n | R(%) | n | R(%) | n | R(%) | n | R(%) | n | R(%) | n | R(%) | n | R(%) | n | R(%) | |
| Penicillins | ||||||||||||||||
| Piperacillin (100ug) | 343 | 71.1 | 948 | 79.4 | 2652 | 81.1 | 4883 | 79 | 90 | 56.7 | 278 | 48.9 | 738 | 49.7 | 1960 | 52 |
| β-Lactam combination agents | ||||||||||||||||
| Ampicillin clavulanic acid (20/10ug) | 328 | 22 | 859 | 17.2 | 2468 | 17.7 | 4968 | 14.1 | 95 | 28.4 | 262 | 17.6 | 701 | 19.5 | 2005 | 29.6 |
| Cefoperazone sulbactam (75/75ug) | / | / | 930 | 9.2 | 2479 | 5.5 | 2962 | 7.6 | 48 | 18.8 | 259 | 12 | 688 | 9.3 | 1260 | 30.8 |
| Piperacillin Tazobactam (100/10ug) | / | / | / | / | 2062 | 4.7 | 6619 | 3.7 | / | / | 120 | 20.8 | 587 | 9.9 | 2560 | 20.4 |
| Cephems (including cephalosporins I, II, III, and IV) | ||||||||||||||||
| Cefuroxime (30ug) | 304 | 31.9 | 893 | 57.7 | 2520 | 68.4 | 5228 | 61.5 | 82 | 42.7 | 270 | 42.2 | 715 | 44.1 | 1889 | 45.8 |
| Ceftazidime (30ug) | 352 | 10.5 | 1015 | 17.7 | 2904 | 30.1 | 7137 | 26.6 | 96 | 24 | 290 | 25.9 | 810 | 27.7 | 2680 | 31.6 |
| Cefotaxime (30ug) | 356 | 31.7 | 989 | 56.6 | 2611 | 67.3 | 4467 | 62.5 | 97 | 42.3 | 288 | 41.7 | 695 | 44.3 | 1814 | 49.7 |
| Cefepime (30ug) | / | / | 973 | 33.4 | 2812 | 48.8 | 7122 | 41.3 | 38 | 39.5 | 279 | 29 | 780 | 30.1 | 2688 | 33.6 |
| Cefoxitin (30ug) | / | / | 824 | 12.7 | 2393 | 11.5 | 5136 | 7.5 | / | / | 239 | 18 | 674 | 13.9 | 1866 | 25.2 |
| Monobactams | ||||||||||||||||
| Aztreonam (30ug) | 329 | 14.6 | 969 | 25.6 | 2684 | 40.9 | 5704 | 37 | 90 | 34.4 | 278 | 25.9 | 745 | 30.2 | 2283 | 35.2 |
| Carbapenems | ||||||||||||||||
| Imipenem (10ug) | 341 | 2.3 | 1011 | 1.8 | 2850 | 1 | 7173 | 0.8 | 88 | 9.1 | 289 | 2.4 | 802 | 3.7 | 2685 | 15.8 |
| Meropenem (10ug) | / | / | 366 | 0.8 | 1988 | 1.2 | 6331 | 1.3 | / | / | 113 | 1.8 | 567 | 4.4 | 2372 | 17.5 |
| Aminoglycosides | ||||||||||||||||
| Amikacin (30ug) | 352 | 9.1 | 964 | 6 | 2870 | 6.2 | 6900 | 2.4 | 95 | 23.2 | 280 | 6.8 | 806 | 5.7 | 2620 | 12.7 |
| Gentamicin (10ug) | 352 | 47.4 | 992 | 55.1 | 2775 | 52.5 | 7152 | 39.5 | 96 | 35.4 | 285 | 23.2 | 793 | 25.7 | 2694 | 28.8 |
| Fluoroquinolones | ||||||||||||||||
| Ciprofloxacin (5ug) | 360 | 52.8 | 973 | 55.6 | 2448 | 54.3 | 7091 | 47.3 | 97 | 18.6 | 285 | 19.3 | 722 | 18.1 | 2668 | 27.7 |
| Levofloxacin (5ug) | / | / | 702 | 52.8 | 2190 | 54.6 | 6448 | 45.2 | / | / | 193 | 11.9 | 601 | 13.5 | 2511 | 25.5 |
| Folate pathway antagonists | ||||||||||||||||
| Trimethoprim/sulfamethoxazole (1.25/23.75ug) | 351 | 72.1 | 980 | 72.2 | 2636 | 62.8 | 7101 | 56.6 | 95 | 44.2 | 288 | 46.9 | 723 | 38.7 | 2673 | 31.6 |
Note: “/” indicated that the antibiotics had not been tested.