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. 2019 Dec 25;48(6):688–694. [Article in Chinese] doi: 10.3785/j.issn.1008-9292.2019.12.15

表1 KZR-504及衍生物的蛋白酶体抑制活性及选择性 [ 15]

Table 1 Proteasome inhibitory activities and selectivities of KZR-504 and its derivatives [ 15]   (μmol/L)

化合物

蛋白酶体抑制活性(IC 50)

选择性(β1c/β1i)

β1i

β1c

KZR-504

0.05

46.35

927

类似物1

0.11

>222

>2000

类似物2

0.14

91.07

651

IC 50：半抑制浓度.