表2 ONX-0914及衍生物的蛋白酶体抑制活性及选择性 ^{[ 12, 18]}

Table 2 Proteasome inhibitory activities and selectivities of ONX-0914 and its derivatives ^{[ 12, 18]}   (nmol/L)

化合物	蛋白酶体抑制活性(IC 50)	选择性(β5c/β5i)
β1i	β1c	β2i	β2c	β5i	β5c
ONX-0914	460	>10 4	590	1100	5.7	54	9
PR-924	1840	>10 4	>10 4	>10 4	2.5	227	91
LU-005i	300	>10 4	410	2500	6.6	287	43
LU-025i	>10 4	>10 4	>10 4	>10 4	36	1900	53
LU-045i	>10 4	>10 4	>10 4	>10 4	32	827	26
LU-015i	7100	>10 4	>10 4	>10 4	8.3	4600	553