Table 2.
Evaluation of the resection specimens comparing the three age groups pre-, peri- and post-screening, divided by the used treatment concept
| Total | Total no neoadjuvant therapy | No neoadjuvante therapy | p-value | Total neoadjuvant therapy | Neoadjuvant therapy | p-value | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre-screening (< 50 years) | Peri-screening (50–69 years) | Post-screening (≥ 70 years) | Fisher´s exact test | Pre-screening (< 50 years) | Peri-screening (50–69 years) | Post-screening (≥ 70 years) | Fisher´s exact test | ||||||||||||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||||||||||
| ICD-M (grouped) | 2.886 | 2.453 | 0.000 | 433 | 0.062 | ||||||||||||||||
| Invasive carcinoma not specified | 1.886 (65.3) | 1.569 (64.0) | 330 (67.2) | 760 (64.4) | 479 (61.3) | 317 (73.2) | 161 (74.9) | 127 (70.2) | 29 (78.4) | ||||||||||||
| Lobular carcinoma not specified | 425 (14.7) | 358 (14.6) | 49 (10.0) | 167 (14.1) | 142 (18.2) | 67 (15.5) | 28 (13.0) | 36 (19.9) | 3 (8.1) | ||||||||||||
| Medullary carcinoma not specified. atypical medullary carcinoma | 56 (1.9) | 40 (1.6) | 15 (3.1) | 15 (1.3) | 10 (1.3) | 16 (3.7) | 9 (4.2) | 7 (3.9) | 0 (0.0) | ||||||||||||
| Tubular adenocarcinoma | 42 (1.5) | 39 (1.6) | 7 (1.4) | 22 (1.9) | 10 (1.3) | 3 (0.7) | 3 (1.4) | 0 (0.0) | 0 (0.0) | ||||||||||||
| Intraductal papillary adenocarcinoma with invasion | 17 (0.6) | 16 (0.7) | 1 (0.2) | 7 (0.6) | 8 (1.0) | 1 (0.2) | 0 (0.0) | 0 (0.0) | 1 (2.7) | ||||||||||||
| Metaplastic carcinoma not specified | 10 (0.3) | 9 (0.4) | 1 (0.2) | 3 (0.3) | 5 (0.6) | 1 (0.2) | 0 (0.0) | 1 (0.6) | 0 (0.0) | ||||||||||||
| Mucinous carcinoma | 44 (1.5) | 41 (1.7) | 1 (0.2) | 11 (0.9) | 29 (3.7) | 3 (0.7) | 2 (0.9) | 1 (0.6) | 0 (0.0) | ||||||||||||
| Other subtypes | 90 (3.1) | 81 (3.3) | 9 (1.8) | 37 (3.1) | 35 (4.5) | 9 (2.1) | 2 (0.9) | 4 (2.2) | 3 (8.1) | ||||||||||||
| In-situ carcinoma | 316 (10.9) | 300 (12.2) | 78 (15.9) | 159 (13.5) | 63 (8.1) | 16 (3.7) | 10 (4.7) | 5 (2.8) | 1 (2.7) | ||||||||||||
| pT category | 2.887 | 2.454 | 0.000 | 433 | 0.037 | ||||||||||||||||
| T0 | 81 (2.8) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 81 (18.7) | 43 (20.0) | 35 (19.3) | 3 (8.1) | ||||||||||||
| Tis | 321 (11.1) | 301 (12.3) | 77 (15.7) | 160 (13.6) | 64 (8.2) | 20 (4.6) | 12 (5.6) | 6 (3.3) | 2 (5.4) | ||||||||||||
| T1mi | 15 (0.5) | 13 (0.5) | 4 (0.8) | 7 (0.6) | 2 (0.3) | 2 (0.5) | 1 (0.5) | 1 (0.6) | 0 (0.0) | ||||||||||||
| T1a | 112 (3.9) | 81 (3.3) | 19 (3.9) | 36 (3.0) | 26 (3.3) | 31 (7.2) | 21 (9.8) | 10 (5.5) | 0 (0.0) | ||||||||||||
| T1b | 407 (14.1) | 375 (15.3) | 70 (14.3) | 203 (17.2) | 102 (13.0) | 32 (7.4) | 21 (9.8) | 9 (5.0) | 2 (5.4) | ||||||||||||
| T1c | 1.038 (36.0) | 958 (39.0) | 175 (35.6) | 482 (40.8) | 301 (38.5) | 80 (18.5) | 41 (19.1) | 30 (16.6) | 9 (24.3) | ||||||||||||
| T2 | 726 (25.2) | 612 (24.9) | 125 (25.5) | 257 (21.8) | 230 (29.4) | 114 (26.3) | 51 (23.7) | 51 (27.6) | 13 (35.1) | ||||||||||||
| T3 | 164 (5.7) | 98 (4.0) | 21 (4.3) | 32 (2.7) | 45 (5.8) | 66 (15.2) | 24 (11.2) | 36 (19.9) | 6 (16.2) | ||||||||||||
| T4a | 1 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.2) | 0 (0.0) | 1 (0.6) | 0 (0.0) | ||||||||||||
| T4b | 13 (0.5) | 9 (0.4) | 0 (0.0) | 2 (0.2) | 7 (0.9) | 4 (0.9) | 1 (0.5) | 2 (1.1) | 1 (2.7) | ||||||||||||
| T4d | 5 (0.2) | 4 (0.2) | 0 (0.0) | 0 (0.0) | 4 (0.5) | 1 (0.2) | 0 (0.0) | 1 (0.6) | 0 (0.0) | ||||||||||||
| TX | 4 (0.1) | 3 (0.1) | 0 (0.0) | 2 (0.2) | 1 (0.1) | 1 (0.2) | 0 (0.0) | 0 (0.0) | 1 (2.7) | ||||||||||||
| rpT-category | 2.885 | 2.453 | 0.068 | 432 | 0.001 | ||||||||||||||||
| Relapse | 92 (3.2) | 89 (3.6) | 10 (2.0) | 44 (3.7) | 35 (4.5) | 3 (0.7) | 0 (0.0) | 0 (0.0) | 3 (8.3) | ||||||||||||
| No relapse | 2.793 (96.8) | 2.364 (96.4) | 481 (98.0) | 1136 (96.3) | 747 (95.5) | 429 (99.3) | 215 (100) | 181 (100) | 33 (91.7) | ||||||||||||
| pT(m)-category | 2.566 | 2.153 | 0.489 | 413 | 0.966 | ||||||||||||||||
| Multiple lesions | 320 (12.5) | 283 (13.1) | 57 (13.8) | 125 (12.2) | 101 (14.1) | 37 (9.0) | 19 (9.4) | 15 (8.6) | 3 (8.6) | ||||||||||||
| No multiple lesions | 2.246 (87.5) | 1.870 (86.9) | 357 (86.2) | 896 (87.8) | 617 (85.9) | 376 (91.0) | 184 (90.6) | 160 (91.4) | 32 (91.4) | ||||||||||||
| pN category | 2.665 | 2.239 | 0.012 | 426 | 0.171 | ||||||||||||||||
| N0 | 1.871 (70.2) | 1.607 (71.8) | 305 (68.7) | 799 (74.5) | 502 (69.7) | 264 (62.0) | 139 (65.3) | 105 (59.7) | 20 (54.1) | ||||||||||||
| N1mi | 73 (2.7) | 60 (2.7) | 18 (4.1) | 23 (2.1) | 19 (2.6) | 13 (3.1) | 8 (3.8) | 5 (2.8) | 0 (0.0) | ||||||||||||
| N1a | 421 (15.8) | 339 (15.1) | 77 (17.3) | 154 (14.4) | 108 (15.0) | 82 (19.2) | 42 (19.7) | 31 (17.6) | 9 (24.3) | ||||||||||||
| N1b | 1 (0.0) | 1 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.5) | ||||||||||||
| N1c | 2 (0.1) | 2 (0.1) | 0 (0.0) | 0 (0.0) | 2 (0.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||||||||||
| N2a | 142 (5.3) | 97 (4.3) | 23 (5.2) | 45 (4.2) | 29 (4.0) | 45 (10.6) | 19 (8.9) | 22 (12.5) | 4 (10.8) | ||||||||||||
| N3a | 77 (2.9) | 58 (2.6) | 10 (2.3) | 18 (1.7) | 30 (4.2) | 19 (4.5) | 5 (2.3) | 11 (6.3) | 3 (8.1) | ||||||||||||
| NX | 78 (2.9) | 75 (3.3) | 11 (2.5) | 34 (3.2) | 30 (4.2) | 3 (0.7) | 0 (0.0) | 2 (1.1) | 1 (2.7) | ||||||||||||
| pL category | 2.563 | 2.165 | 0.002 | 398 | 0.118 | ||||||||||||||||
| L0 | 2.207 (86.1) | 1.887 (87.2) | 346 (82.8) | 924 (89.6) | 617 (86.2) | 320 (80.4) | 155 (78.7) | 141 (84.4) | 24 (70.6) | ||||||||||||
| L1 | 353 (13.8) | 275 (12.7) | 72 (17.2) | 106 (10.3) | 97 (13.5) | 78 (19.6) | 42 (21.3) | 26 (15.6) | 10 (29.4) | ||||||||||||
| LX | 3 (0.1) | 3 (0.1) | 0 (0.0) | 1 (0.1) | 2 (0.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||||||||||
| pV-categroy | 2.563 | 2.164 | 0.013 | 399 | 1.000 | ||||||||||||||||
| V0 | 2.525 (98.5) | 2.137 (98.8) | 413 (99.0) | 1.024 (99.3) | 700 (97.8) | 388 (97.2) | 193 (97.5) | 162 (97.0) | 33 (97.1) | ||||||||||||
| V1 | 37 (1.4) | 26 (1.2) | 4 (1.0) | 6 (0.6) | 16 (2.2) | 11 (2.8) | 5 (2.5) | 5 (3.0) | 1 (2.9) | ||||||||||||
| VX | 1 (0.0) | 1 (0.0) | 0 (0.0) | 1 (0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||||||||||
| Pn-category | 899 | 706 | 0.105 | 193 | 0.824 | ||||||||||||||||
| Pn0 | 832 (92.5) | 652 (92.4) | 129 (96.3) | 254 (90.4) | 269 (92.4) | 180 (93.3) | 90 (92.8) | 75 (92.6) | 15 (100) | ||||||||||||
| Pn1 | 67 (7.5) | 54 (7.6) | 5 (3.7) | 27 (9.6) | 22 (7.6) | 13 (6.7) | 7 (7.2) | 6 (7.4) | 0 (0.0) | ||||||||||||
| Grading | 2.119 | 2.119 | 0.000 | ||||||||||||||||||
| G1 | 481 (22.7) | 481 (22.7) | 97 (23.7) | 241 (24.0) | 143 (20.3) | ||||||||||||||||
| G2 | 1.251 (59.0) | 1.251 (59.0) | 209 (51.0) | 600 (59.6) | 442 (62.9) | ||||||||||||||||
| G3 | 387 (18.3) | 387 (18.3) | 104 (25.4) | 165 (16.4) | 118 (16.8) | ||||||||||||||||
| pR-status | 2.863 | 2.445 | 0.037 | 418 | 0.757 | ||||||||||||||||
| R0 | 2.818 (98.5) | 2.409 (98.5) | 481 (98.2) | 1.167 (99.2) | 761 (97.7) | 409 (97.8) | 200 (98.0) | 174 (97.8) | 35 (97.2) | ||||||||||||
| R1 | 27 (0.9) | 23 (0.9) | 5 (1.0) | 7 (0.6) | 11 (1.4) | 4 (1.0) | 2 (1.0) | 2 (1.1) | 0 (0.0) | ||||||||||||
| RX | 18 (0.6) | 13 (0.5) | 4 (0.8) | 2 (0.2) | 7 (0.9) | 5 (1.2) | 2 (1.0) | 2 (1.1) | 1 (2.8) | ||||||||||||