Table 4.
Characteristics of mutation units types of EGFR in 802 NSCLC patients analysis by NGS
| Exons | Sites | Mutations | Amino acid sequence changes | Unit positive case (n) | Unit point mutation rate (%) | Total mutation rate of exon (%) | Composition ratio (%) |
|---|---|---|---|---|---|---|---|
| G719X | 11 | 1.4 | 1.9 | 3.5 | |||
| G719A | 2156G>C | ||||||
| 18 | 3 | G719S | 2155G>A | ||||
| G719C | 2155G>T | ||||||
| E709 | 4 | 0.5 | |||||
| 19 | 19 | 19del- | 124 | 15.5 | 15.5 | 29.2 | |
| E746-A750del | 2236-2250del | ||||||
| S752-I759del | 2254-2277del | ||||||
| The rest are not listed | |||||||
| 20 | 5 | T790M | 2369C>T | 31 | 3.9 | 6.9 | 13.0 |
| S768I | 2303G>T | 4 | 0.5 | ||||
| 20Ins | 16 | 2.0 | |||||
| The rest are not listed | 4 | 0.5 | |||||
| 21 | 2 | L858R | 2573T>G | 156 | 19.5 | 20.9 | 49.1 |
| L861Q | 2582T>A | 11 | 1.4 | ||||
| Rare mutation | 5 | 5 | 0.6 | 1.2 | |||
| 5 | p.R547* | ||||||
| 17 | p.R677C | ||||||
| 27 | p.E1079K | ||||||
| 15 | p.C624Y | ||||||
| Exon28_Intron4 | EGFR-PPP1R17 | ||||||
| Gene amplification | 58 | 7.2 | 13.7 |
The mutation of EGFR gene in patients with advanced NSCLC was detected by ARMS-PCR. Unit point mutation rate = the number of mutations per unit point/total number of mutations
NSCLC non-small cell lung cancer, EGFR epidermal growth factor receptor, § include 209 single-site mutation patients and 131 multiple locus mutation patients