Table 5.

Comparison of the two methods for detecting mutation rates of EGFR gene

Relevant factors	Method	Wild type	Mutant type	Mutation rate (%)	χ2 (Bray et al. 2018)	P
Exon 18	ARMS-PCR NGS	3603 787	62 15	1.8 1.9	0.124	0.725
Exon 19	ARMS-PCR	2908	757	20.7	11.21	0.001
	NGS	678	124	15.5
Exon 20	ARMS-PCR	3551	114	3.1	25.384	0.000
	NGS	747	55	6.9
Exon 21	ARMS-PCR	2760	905	24.7	5.403	0.020
	NGS	635	167	39.4
Multiple locus mutations	ARMS-PCR		90	2.7	269.319	0.000
	NGS		131	16.3
Total	ARMS-PCR	1921	1744	47.6	7.125	0.008
	NGS	462	340	42.4

Comparison of mutation rates of exon-related mutation sites detected by the two methods. The mutation rates were compared by row X list Chi-square test, and P