Table 3.

Drugs involved in interacting drug combinations (in alphabetic order)

Combination of drugs with a potential for QT prolongation (258 combinations among all patients)
Cancer therapy	Arsenic trioxide, bendamustine, eribulin, fluorouracil, oxaliplatin
Other therapy	Sympathomimetics: indacaterol, formoterol, salmeterol Psychiatric medications: amitriptyline, doxepin, escitalopram, melperone, mirtazapine, opipramol, quetiapine, venlafaxine Proton pump inhibitors: pantoprazole, omeprazole, esomeprazole Anti-infectives: amphotericin B, ciprofloxacin, co-trimoxazole, fluconazole, posaconazole, voriconazole 5-HT3 receptor antagonists: granisetron, ondansetron Others: alfuzosin, pregabalin, tramadol, ebastine, ivabradine
Combination of drugs with myelotoxicity (107 combinations among all patients)
Cancer therapy	Antibodies: rituximab, trastuzumab Anthracyclines: daunorubicin, doxorubicin, epirubicin Platin-based: cisplatin, carboplatin Pyrimidine analogues: capecitabine, cytarabine, fluorouracil, gemcitabine Taxanes: docetaxel, paclitaxel Vinca alkaloids: vinblastine, vincristine Others: bleomycin, cyclophosphamide, dacarbazine, etoposide, fludarabine, hydroxycarbamide, irinotecan, methotrexate, mitoxantrone
Other therapy	Acetaminophen, allopurinol, co-trimoxazole, enalapril, glimepiride, hydrochlorothiazide, mesalazine, metamizole, mirtazapine, zoledronic acid, ramipril
Combination of drugs with hepatotoxicity (81 combinations among all patients)
Cancer therapy	Anthracyclines: daunorubicin, doxorubicin, epirubicin Others: cytarabine, gemcitabine, methotrexate, paclitaxel, topotecan, tretinoin
Other therapy	Statins: atorvastatin, simvastatin Anti-infectives: ciprofloxacin, co-trimoxazole, metronidazole, fluconazole, voriconazole ACE inhibitors: enalapril, lisinopril, perindopril, ramipril Others: acetaminophen, lorazepam, testosterone, thiamazole
CYP3A4 interactions (46 combinations among all patients) (Anticancer pharmaceuticals are written in italics)
Substrates	Amlodipine, atorvastatin, clopidogrel, cyclophosphamide, dexamethasone, esomeprazole, fentanyl, irinotecan, omeprazole, ondansetron, pantoprazole, quetiapine, simvastatin, tramadol, venetoclax, vinblastine, vincristine
Inhibitors	Aprepitant, ciprofloxacin, fluconazole, idelalisib, ranolazine, voriconazole
Inducers	Glucocorticoids