Table 4.

Likely Interactions between CAM supplements and cancer treatment in seven patients

	Anticancer drug	CAM supplement	Interaction (likely)/effect
1	Paclitaxel	Mistletoe	Increased effects of paclitaxel by inhibiting ribosomal protein synthesis (Pae et al. 2001)
2	Bortezomib	Vitamin C	Reduction of effects of bortezomib (Perrone et al. 2009)
	Bortezomib Dexamethasone	Chinese herbs	Chinese herbs are rated as likely interacting, CYP effects likely (Zeller et al. 2013)
	Bortezomib Dexamethasone	Ginger	Increased levels of bortezomib and dexamethasone due to CYP3A4 inhibition by ginger (Cho and Yoon 2015; JANSSEN-CILAG INTERNATIONAL NV 2019; Kimura et al. 2010; Qiu et al. 2015; ratiopharm GmbH 2020a)
3	Bortezomib Dexamethasone	Ginger	Increased levels of bortezomib and dexamethasone due to CYP3A4 inhibition by ginger (Cho and Yoon 2015; JANSSEN-CILAG INTERNATIONAL NV 2019; Kimura et al. 2010; Qiu et al. 2015; ratiopharm GmbH 2020a)
4	Irinotecan	Ginger	Increased levels of irinotecan due to CYP3A4 inhibition by ginger (Cho and Yoon 2015; Kimura et al. 2010; Petri 2017; Qiu et al. 2015)
5 + 6	Doxorubicin	Vitamin C	Reduction of effects of anthracyclines on tumor cells (Heaney et al. 2008; Zeller et al. 2013)
7	Epirubicin	Vitamin C	Reduction of effects of anthracyclines on tumor cells (Zeller et al. 2013)