Table 3.
Univariate and multivariate analyses of factors associated with overall survival
| Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| High IL-6 | 4.1 (1.9–8.9) | < 0.001 | 2.99 (1.22–7.3) | 0.017 |
| High IL-8 | 2.4 (1.2–4.7) | 0.009 | 2.19 (1.02–4.7) | 0.044 |
| Sex (male vs. female) | 0.79 (0.28–2.3) | 0.667 | ||
| Age (≥ 65 vs. < 65 years) | 1.1 (0.55–2.1) | 0.85 | ||
| ECOG PS (1 vs. 0) | 0.63 (0.28–1.4) | 0.263 | ||
| Cirrhosis (yes vs. no) | 0.63 (0.24–1.7) | 0.35 | ||
| Hepatitis B etiology (yes vs. no) | 1.1 (0.34–3.7) | 0.865 | ||
| Hepatitis C etiology (yes vs. no) | 1.5 (0.68–3.1) | 0.335 | ||
| Alcohol etiology (yes vs. no) | 0.61 (0.3–1.2) | 0.164 | ||
| TACE history (Yes vs. No) | 1.2 (0.61–2.5) | 0.578 | ||
| PVI (yes vs. no) | 0.55 (0.27–1.1) | 0.099 | 0.66 (0.29–1.53) | 0.337 |
| Child–Pugh score (B vs. A) | 1.5 (0.59–4.1) | 0.377 | ||
| BCLC stage (C vs. B) | 0.57 (0.26–1.2) | 0.155 | ||
| Beyond up-to-7 (yes vs. no) | 1.5 (0.44–4.8) | 0.536 | ||
| Tumor diameter (≥ 65 vs. < 65 mm) | 2.2 (1.1–4.4) | 0.021 | 1.31 (0.54–3.18) | 0.545 |
| AFP (≥ 400 vs < 400 ng/mL) | 1.1 (0.54–2.4) | 0.745 | ||
| Diffuse disease (≥ 10 lesions) | 1.3 (0.64–2.7) | 0.457 | ||
| Extrahepatic disease | 1.6 (0.48–5.5) | 0.431 | ||
| Albumin | 0.37 (0.17–0.77) | 0.008 | 0.72 (0.29–1.8) | 0.483 |
| Bilirubin | 0.51 (0.25–1) | 0.058 | 0.83 (0.38–1.84) | 0.649 |
Bold type indicates statistical significance