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. 2022 Jan 30;26:33. doi: 10.1186/s13054-021-03877-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Absolute risks of liberation from mechanical ventilation and of death on mechanical ventilation comparing patients with levels at the 25th percentile with patients with levels at the 75th percentile of Syndecan-1, Soluble Thrombomodulin (sTM) and Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) respectively. Solid lines are point estimates and dashed lines represent 95% confidence intervals. The absolute risks are calculated based on the cause specific hazard rates for the represented outcomes, obtained from multivariable competing risks Cox regressions introducing Syndecan-1, sTM or PECAM-1 as continuous variables. The absolute risks are calculated for a 71-year old female, with no chronic obstructive pulmonary disease, no chronic heart failure, no respiratory infection at baseline, no acute kidney injury at baseline, with a Bilirubin of 10.7 µmol/L and a PaO₂/FiO₂-ratio of 21.4 kPa