Generalized pustular psoriasis (GPP) is a rare, neutrophilic skin disease characterized by sudden episodes of widespread rash and sterile pustules.

While GPP can present with pre-existing plaque psoriasis, it is now recognized as a separate clinical entity with clear distinctions in genetic and immunologic determinants and response to treatment.

Identifying a key role for the interleukin-36 immune signaling pathway in the pathogenesis of GPP has paved the way for the development of new therapies.