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. 2022 Jan 17;12:749049. doi: 10.3389/fphys.2021.749049

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Copyright © 2022 Poggiogalle, Rossignon, Carayon, Capel, Rigaudière, De Saint Vincent, Le-Bacquer, Salles, Giraudet, Patrac, Lebecque, Walrand, Boirie, Martin and Guillet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Body weight, fat-free mass (FFM), and fat mass (FM) at baseline. (D) %Δ body weight. Diet main effect, p = 0.004; age group main effect, p = 0.044; diet × age group interaction, (p = n.s.). § diet effect (same age) in the old group: ST12 vs. HF12, p = 0.039; * age effect (same diet) in ST12 rats, p = 0.013. (E) %Δ fat-free mass (FFM): § diet effect (same age) in the old group ST25 vs. ST12, p = 0.048. (F) %Δ fat mass (FM): diet main effect, p < 0.001; age group main effect, n.s.. § diet effect (same age) in the adult group: HF12 vs. ST12, p = 0.007; HF12 vs. ST25, p = 0.007. § diet effect (same age) in the old group HF12 vs. ST12, p < 0.001, and HF12 vs. ST25, p < 0.001. Adult rats: ST12 (n = 12); ST25 (n = 12); HF12 (n = 12); HF25 (n = 11). Old rats: ST12 (n = 11); ST25 (n = 11); HF12 (n = 9); HF25 (n = 7).