Table 2.
Representative antibodies against synaptic or other neuronal cell surface proteins and their associated clinical syndromes.
| Anti-body | Major clinical syndromes | Major associated neoplasms |
|---|---|---|
| AntiAMPAR | Limbic encephalitis | Small cell lung carcinoma Breast carcinoma Thymoma |
| Anti-Caspr2 | Limbic encephalitis Morvan's syndrome |
Tumor associations uncommon (Thymoma) |
| Anti-DPPX | Encephalopathy Myelopathy GI dysmotility |
Tumor associations uncommon (Lymphoma) |
| Anti-DR2 | Parkinsonism Encephalitis |
No tumor association reported |
| Anti-GABAAR | Encephalitis Epilepsy |
Tumor association uncommon (Thymoma, Hodgkin's disease, multiple myeloma) |
| Anti-GABABR | Epilepsy Limbic encephalitis Opsoclonus myoclonus |
Small cell lung cancer |
| Anti-Glycine receptor | PERM Stiff Person Spectrum Disorder |
Tumor associations uncommon |
| Anti-IGLON5 | Dementia Sleep disorder Respiratory impairment |
(Thymoma) |
| Anti-NMDAR | Limbic encephalitis Psychosis Epilepsy Movement disorders Psychosis Catatonia |
Ovarian or testicular teratoma |
| Anti-mGluR1 | Cerebellar ataxia | Hodgkin's disease |
| Anti-mGluR5 | Limbic encephalitis “Ophelia syndrome” |
Hodgkin's disease |
| Anti-P/Q type VGCC | Cerebellar ataxia (Lambert-Eaton myasthenic syndrome) | Small cell lung cancer |
AMPAR, 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid receptor; Caspr2, contactin-associated protein-like 2; DPPX, dipeptidyl-peptidase-like protein 6 encephalitis; D2R, dopamine 2 receptor; GABA, γ-aminobutyric acid; LGI1, Leucine-rich glioma-inactivated NMDA-R, anti-N-methyl D-aspartate receptor encephalitis; mGluR1, metabotropic glutamate receptor 1; VGCC, voltage-gated calcium channel.