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. 2022 Jan 17;11:790481. doi: 10.3389/fonc.2021.790481

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Copyright © 2022 Butzmann, Sridhar, Jangam, Song, Singh, Kumar, Chisholm, Pinsky, Huang and Ohgami

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis for promoter region, promoter flanking regions, and transcription binding sites (CTCF). The top part of the figure shows the observed versus expected number of mutations. In the bottom part of the figure, the mutational burden within the same non-coding gene regions for both groups are demonstrated as the log2 ratio of the number of observed and expected point mutations indicating the effect size of the enrichment or depletion within each region. (*) = statistical significance (p<0.05; two‐sided binomial test).