Table 1.
Summary of body weight, food consumption, fertility, and mid-gestation uterine examination data from the fertility study in rats.
| Dose (mg/kg/day) |
||||
|---|---|---|---|---|
| 0 | 60 | 200 | 1000 | |
| Number of females/males | 20/20 | 20/20 | 20/20 | 20/20 |
| Male Terminal Body Weight (g) | 408.9 ± 23.1a | 409.9 ± 22.7 | 411.6 ± 22.2 | 408.9 ± 19.7 |
| Male Food Consumption (g/day) | ||||
| Premating Day 1−14 | 22.4 ± 1.3 | 22.0 ± 1.1 | 23.0 ± 1.2 | 20.9 ± 0.9* |
| Mating Day 15−19 | 18.4 ± 2.2 | 19.3 ± 2.8 | 18.0 ± 3.1 | 18.3 ± 3.2 |
| Female Terminal Body Weight (g) | 273.6 ± 15.8 | 277.0 ± 24.1 | 272.0 ± 13.3 | 277.8 ± 14.1 |
| Female Food Consumption (g/day) | ||||
| Premating Day 1−14 | 14.7 ± 0.7 | 15.3 ± 1.2 | 14.8 ± 0.8 | 14.7 ± 1.0 |
| Gestation Day 0−14 | 19.2 ± 2.0 | 19.2 ± 2.1 | 19.0 ± 2.2 | 19.0 ± 1.6 |
| Fertility Data | ||||
| Mean no. of estrous cycles | 2.8 ± 0.4 | 2.7 ± 0.5 | 2.7 ± 0.5 | 2.6 ± 0.5 |
| Precoital interval (days)b | 3.7 ± 3.5 | 3.6 ± 3.5 | 3.0 ± 2.2 | 3.2 ± 2.9 |
| Mating index (%)c | 20/20 (100 %) | 20/20 (100 %) | 20/20 (100 %) | 20/20 (100 %) |
| Fecundity Index (%)d | 20/20 (100 %) | 19/20 (95 %) | 18/20 (90 %) | 20/20 (100 %) |
| Fertility Index (%)e | 20/20 (100 %) | 19/20 (95 %) | 18/20 (90 %) | 20/20 (100 %) |
| Number of pregnant females | 20 | 19 | 18 | 20 |
| Uterine Examination Data | ||||
| Corpora lutea | 13.3 ± 1.5 | 13.8 ± 1.3 | 14.1 ± 1.7 | 12.7 ± 1.6 |
| Implantation sites | 10.3 ± 4.2 | 12.5 ± 1.4 | 12.6 ± 3.0 | 10.5 ± 3.1 |
| Live embryos | 8.9 ± 4.4 | 11.8 ± 1.4 | 11.5 ± 3.2 | 9.6 ± 3.2 |
| Resorptions | 1.4 ± 1.3 | 0.7 ± 0.7 | 1.1 ± 1.6 | 1.0 ± 0.8 |
| Preimplantation loss (%) | 23.8 ± 28.9 | 9.7 ± 8.1 | 11.0 ± 18.4 | 16.9 ± 22.8 |
| Postimplantation loss (%) | 18.1 ± 24.2 | 5.3 ± 5.7 | 9.5 ± 12.8 | 10.6 ± 11.9 |
*
p ≤ 0.05.
a
Data presented as mean per group ± standard deviation.
b
Precoital interval is the number of days cohabitated before confirmed copulation (sperm observed in vaginal smear or copulatory plug observed in vagina).
c
Mating index is the number of mating pairs with confirmed mating/the number of mating pairs cohabitated.
d
Fecundity index is the number of mating pairs with a pregnant female/the number of mating pairs with confirmed copulation.
e
Fertility index is the number of mating pairs with a pregnant female/the number of mating pairs cohabitated.