TABLE 3.

Apoptosis-related circular RNAs in brain tumors.

	Genomic coordinate	Brain tumors	Circular RNAs	CircbaseID	Targets	Model	Type of cell line	Ref
Up regulated circular RNA expression	q21.3 chr1:151206672–151212515 (+)	Glioblastoma	CircPIP5K1A	hsa_circ_0014130	PI3K/AKT	In vivo	U87, TJ861, TJ905, U251, H4, A172 glioma tissues	Zheng et al. (2021)
						In vitro	mice
	q26.2 chr3:170013698–170015181 (+)	Glioblastoma	CircPRKCI	hsa_circ_0067934	PI3K-AKT pathway	In vitro	GBM samples	Xin et al. (2019)
							The LN18, U251, LN229, T98G and A172 cells
	q26.2 chr3:170013698–170015181 (+)	Glioblastoma	CircPRKCI	hsa_circ_0067934	caspase-3, caspase-9 and PARP	In vivo	A172 glioma cells/human glioma tissues/mice	Zhang et al. (2019b)
						In vitro
	q14.2 chr5:82832825–82838087 (+)	glioblastoma	CircVCAN	hsa_circ_0073237	microRNA-1183	In vitro	The 293T, U87, and U251 cells glioma tissues/mice	Zhu et al. (2020)
	p21.2 chr6:37787306–38084515 (+)	Glioblastoma	CircZFAND3	hsa_circ_0076248	MiR‐181a/SIRT1	In vivo	Human GBM samples/U251, U87 cell lines	Lei et al. (2019)
						In vitro	Animal studies
	q14.3 chr6:86176777–86197207 (+)	Glioblastoma	CircNT5E	hsa_circ_0077231	NT5E, SOX4, PI3KCA, p-Akt, p-Smad2	In vivo	Tumor tissue samples/GBM cells (U87 and U251)/mice	Wang et al. (2018a)
						In vitro
	q32.1 chr7:128845043–128846428 (+)	Glioblastoma	CircSMO742	hsa_circ_0001742	miR-338-3p/SMO	In vivo	10 human gliomas tissues/human glioblastoma A172 and U-87 MG/mice	Xiong et al. (2019)
						In vitro
	q24.21 chr8:128806778–128903244 (+)	Glioblastoma	CircPVT1	hsa_circ_0085536	miR-199a-5p	In vitro	human GBM tissues U539 and U251 cells	Chi et al. (2020)
					YAP1 and PI3K/AKT
					Capase-3
					Capase-9
					Ncadherin, Vimentin, Zeb1, E-cadherin
	q34.12 chr9:130914461–130915734 (+)	Glioblastoma	CircLCN2	hsa_circ_0088732	N-cadherin, vimentin, E-cadherin	In vivo	tumor tissues/glioma cell lines	Jin et al. (2020b)
						In vitro	LN229, U87-MG, U251, and A172/mice
	q12.11 chr13:21735928–21746820 (-)	Medulloblastoma	CircSKA3	hsa_circ_0029696	miR-383-5p/FOXM1	In vivo	tissue samples/cell lines	Wang et al. (2020c)
					Bcl2 and capase-3	In vitro	DAOY and ONS-76
	q13.3 chr13:38136718–38161065 (-)	Glioblastoma	CircPOSTN	hsa_circ_0030018	Bcl2/bax/caspase 3	In vivo	Human tissue sample/Glioma cell line (U251, LN229)/mice	Long et al. (2020)
						In vitro
	q15.2 chr15:43120125–43164956 (-)	Glioblastoma	CircTTBK2	hsa_circ_0000594	Mirna-520b/EZH2	In vivo	glioma tissues	Yuan et al. (2019)
						In vitro	A172 and U251 mice
	q15.2 chr15:43120125–43164956 (-)	Glioblastoma	CircTTBK2	hsa_circ_0000594	PI3K/AKT and ERK	In vivo	Human tissues specimens/Human U87 and U251 glioma cell lines mice/	Zheng et al. (2017)
						In vitro
	p13.3 chr16:765172–767480 (+)	Glioblastoma	CircMETRN	hsa_circ_0037251	miR-1229-3p/mTOR axis	In vivo	U373, U251 mice	Cao et al. (2019)
						In vitro
	q21.1 chr18:48189458–48190874 (+)	Glioblastoma	CircMAPK4	hsa_circ_0047688	p38/MAPK	In vitro in vivo	U138, U373 and U87 glioma cell lines/glioma tissues/mice	He et al. (2020)
	p13.13 chr19:13183860–13192669 (+)	Glioblastoma	CircNFIX	hsa_circ_0049658	Notch signaling pathway	In vivo	SF-539, SHG-44	Xu et al. (2018b)
						In vitro	U87 glioma tissue from mice
	p13.13 chr19:13183860–13192669 (+)	Glioblastoma	CircNFIX	hsa_circ_0049658	miR-378e/RPN2 axis	In vivo	Patient samples T98, U251, SW1783,A172	Ding et al. (2019)
						In vitro	Mice
	q13.1 chrX:69606467–69607147 (+)	Glioblastoma	CircKIF4A	hsa_circ_0090956	Wnt5a, β-catenin, c-Myc, cyclin D1/bcl2/bax	In vivo	glioma sample LN229, A172, SHG44, U251s mice	Huo et al. (2020)
Down regulated Circular RNA expression	q11.21 chr20:33001547–33037285 (+)	Glioblastoma	CircITCH	hsa_circ_0001141	ITCH-Wnt/β-catenin	In vitro, human	cancer tissues U87, U251, A172, SHG44, LN229, T98G, SHG139	Wang et al. (2018b)