Figure 1.

Longitudinal monitoring of body weight and clinical scores in mice immunized with MOG₃₅₋₅₅ (QuilA-EAE) and their controls (CTL) from post-induction Day 0 (D0) to D40. (A) Time course of body weight. Results are means ± SEM. (B) Time course of EAE clinical score based on physical observation defined by Khan et al. (15) ranging from 0 (normal behavior) to 4 (quadriplegia). Results are means ± SEM. The dashed line represents level of motor defects considered as clinically relevant score (EAE score 1: completely limp tail or hindlimb weakness). Statistical analysis was performed using two-way ANOVA followed by post-hoc Sidak test; ^**p < 0.01, ^***p < 0.001 vs. control (shown for Sidak test only). ^*p < 0.05.