Figure 3.

Evaluation of somatic sensitivity in mice immunized with MOG₃₅₋₅₅ (QuilA-EAE) and their controls (CTL) at post-induction Day 17 (D17) and D30. (A) Mechanical sensitivity from post-induction Day 0 (D0) to D35. Mechanical sensitivity expressed as the mean of paw withdrawal threshold (PWT) ± SEM for each time point. Data are illustrated using time course curves and bar chart showing results obtained at D17 and D30. (B) Heat hyperalgesia at D17 and D30 expressed as the mean time taken to observe a nocifensive behavior in mice exposed to a hotplate ± SEM with hotplate at 52°C (top) and 56°C (bottom). (C) Cold allodynia at D17 and D30 was expressed as the mean number of nociceptive responses ± SEM observed in mice after acetone drop deposition. Statistical analysis was performed using two-way ANOVA followed by post-hoc Sidak test; ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. control (shown for Sidak test only).