Table 4.

Summary table of pharmacological effect of pregabalin on mechanical and thermal sensitivity in mice immunized with MOG₃₅₋₅₅ (QuilA-EAE) and their controls (CTL) during the chronic phase of the disease.

AUC Von Frey 0.4 g	Group	Vehicle	Pregabalin 10 mg/kg	Pregabalin 30 mg/kg
	CTL	125 ± 409.1	−1,325 ± 769.1	−3,258 ± 1025*
	EAE	−1,442 ± 896.5	−2,667 ± 844.6	−4,692 ± 706.1*

Mice received a single intraperitoneal (i.p.) bolus dose of pregabalin at 10 or 30 mg/kg or vehicle (NaCl sterile for injection).

Comparison of area under the curve (AUC) of the percentage of paw withdrawal assessed by von Frey frequency method using calibrated 0.4 g and 1.4 g filaments and the mean latency of the first nocifensive behavior observed on a hotplate at 56°C.

Statistical analysis was performed using one-way ANOVA followed by post-hoc Tukey's test;

^*p < 0.05 vs. vehicle.