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. 2022 Jan 17;12:786334. doi: 10.3389/fphar.2021.786334

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Copyright © 2022 Deng, Huang, Wang, Luo, Liu, Yan, Jiang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Percentage changes in urinary protein, serum albumin, serum creatinine, and eGFR over time. Compared to baseline, at 3, 6, and 12 months, the decrease of urinary protein (A) (p < 0.001, p = 0.016, p < 0.001, respectively) and the increase of serum albumin (B) (p = 0.002, 0.016, 0.001, respectively) more rapid in non-high titer group than in high titer group, while there were no significant differences in the decrease in serum creatinine (C) (p = 0.825, 0.499, 0.440, respectively) and in the increase in eGFR (D) (p = 0.971, 0.291, 0.460, respectively) at 3, 6, and 12 months between the two titer groups. eGFR: estimated glomerular filtration rate. *p < 0.05, **p < 0.01, ***p < 0.001.