TABLE 3.
Factors predicting CR and TR for patients with seropositive PLA2R-associated MN.
| Variables | CR | TR | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
| HR | 95%CI | p-value | HR | 95%CI | p-value | HR | 95%CI | p-value | HR | 95%CI | p-value | |
| Treatment | 0.799 | 0.576, 1.109 | 0.180 | — | — | — | 0.822 | 0.654, 1.032 | 0.091 | — | — | — |
| PLA2Rab titer (RU/ml) | 0.996 | 0.994, 0.997 | <0.001 | 0.997 | 0.995, 0.999 | 0.001 | 0.996 | 0.995, 0.997 | <0.001 | 0.997 | 0.996, 0.998 | <0.001 |
| Age (years) | 0.989 | 0.978, 1.001 | 0.066 | — | — | — | 0.989 | 0.981, 0.997 | 0.009 | 0.990 | 0.976, 1.003 | 0.142 |
| Gender | 0.868 | 0.621, 1.213 | 0.407 | — | — | — | 0.834 | 0.660, 1.054 | 0.129 | — | — | — |
| SBP (mmHg) | 0.993 | 0.983, 1.003 | 0.157 | — | — | — | 0.995 | 0.988, 1.001 | 0.126 | — | — | — |
| DBP (mmHg) | 0.984 | 0.970, 1.000 | 0.044 | 0.990 | 0.974, 1.005 | 0.181 | 0.991 | 0.981, 1.001 | 0.079 | — | — | — |
| Serum creatinine (µmol/L) | 0.995 | 0.989, 1.002 | 0.166 | — | — | — | 0.994 | 0.990, 0.999 | 0.020 | 0.993 | 0.981, 1.006 | 0.291 |
| Serum albumin (g/L) | 1.109 | 1.065, 1.155 | <0.001 | 1.083 | 1.012, 1.159 | 0.021 | 1.110 | 1.080, 1.141 | <0.001 | 1.094 | 1.045, 1.146 | <0.001 |
| eGFR (mL/min/1.73 m2) | 1.006 | 0.999, 1.014 | 0.790 | — | — | — | 1.007 | 1.002, 1.011 | 0.009 | 0.994 | 0.978, 1.009 | 0.421 |
| Urinary protein (g/24 h) | 0.908 | 0.866, 0.951 | <0.001 | 1.033 | 0.962, 1.109 | 0.371 | 0.913 | 0.886, 0.942 | <0.001 | 1.042 | 0.995, 1.091 | 0.078 |
| TG (mmol/L) | 1.007 | 0.935, 1.085 | 0.853 | — | — | — | 0.987 | 0.934, 1.044 | 0.654 | — | — | — |
| TCHO (mmol/L) | 1.002 | 0.938, 1.070 | 0.959 | — | — | — | 0.985 | 0.938, 1.035 | 0.550 | — | — | — |
| HDL-chol (mmol/L) | 0.937 | 0.720, 1.219 | 0.629 | — | — | — | 1.008 | 0.839, 1.212 | 0.929 | — | — | — |
| LDL-chol (mmol/L) | 0.986 | 0.913, 1.064 | 0.719 | — | — | — | 0.962 | 0.910, 1.018 | 0.180 | — | — | — |
Variables with p < 0.20 in the univariable analyses were included in the multivariable analysis. CR, complete remission; TR, total remission; PLA2R, M type phospholipase A2 receptor; MN, membranous nephropathy; HR: hazard ratio; CI, confidence interval; PLA2Rab: antibodies against the M-type phospholipase-A2-receptor; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; TG, triglyceride; TCHO, total cholesterol; HDL-chol: high-density lipoprotein cholesterol; LDL-chol, low-density lipoprotein cholesterol.
The meaning of the bold values is highlight p < 0.05.