TABLE 4.
Comparison of baseline clinical characteristics between CTX subgroup and TAC subgroup in the two titer groups.
| Parameters | High titer group | Non-high titer group | ||||||
|---|---|---|---|---|---|---|---|---|
| Total | CTX subgroup | TAC subgroup | p-value | Total | CTX subgroup | TAC subgroup | p-value | |
| (n = 131) | (n = 71) | (n = 60) | (n = 316) | (n = 204) | (n = 112) | |||
| Age (years) | 55 (47, 63) | 54 (47, 61) | 56 (47, 65) | 0.571 | 42 (53, 64) | 53 (43, 64) | 53 (37, 64) | 0.555 |
| Male gender (%) | 95 (72.52) | 51 (71.83) | 44 (73.33) | 0.848 | 222 (70.25) | 147 (72.06) | 75 (66.96) | 0.344 |
| SBP (mmHg) | 130 (122, 139) | 129 (121, 137) | 132 (122, 140) | 0.287 | 129 (120, 140) | 128 (118, 139) | 130 (120, 141) | 0.117 |
| DBP (mmHg) | 83 (75, 88) | 83 (75, 87) | 83 (72, 92) | 0.897 | 80 (73, 89) | 80 (72, 88) | 81 (74, 90) | 0.244 |
| Serum creatinine (µmol/L) | 82.20 (64.50, 99.13) | 79.00 (62.63, 98.17) | 85.08 (65.42, 101.63) | 0.499 | 77.44 (63.33, 93.54) | 77.95 (64.34, 94.85) | 75.41 (61.49, 90.95) | 0.159 |
| Serum albumin (g/L) | 20.62 (18.20, 22.38) | 20.57 (18.14, 22.80) | 20.74 (18.43, 22.17) | 0.895 | 27.10 (23.10, 28.59) | 26.87 (23.10, 28.51) | 27.25 (22.99, 28.84) | 0.799 |
| eGFR (ml/min/1.73 m2) | 88.93 (75.22, 103.46) | 89.65 (75.90, 105.05) | 89.18 (72.32, 101.82) | 0.695 | 95.41 (73.72, 107.86) | 94.64 (72.87, 107.18) | 96.32 (76.52, 109.91) | 0.289 |
| Urinary protein (g/24 h) | 11.18 (9.51, 13.66) | 10.53 (9.12, 14.38) | 11.70 (10.10, 13.32) | 0.149 | 5.62 (4.33, 7.78) | 4.30 (5.78, 7.59) | 5.51 (4.37, 7.92) | 0.926 |
| TG (mmol/L) | 2.48 (1.75, 3.65) | 2.17 (1.59, 3.58) | 2.53 (1.89, 3.86) | 0.231 | 2.33 (1.64, 3.36) | 2.39 (1.64, 3.38) | 2.23 (1.65, 3.25) | 0.506 |
| TCHO (mmol/L) | 8.51 (7.22, 10.11) | 8.42 (6.91, 10.11) | 8.78 (7.56, 10.15) | 0.451 | 8.03 (6.65, 9.67) | 8.03 (6.80, 9.67) | 7.97 (6.43, 9.64) | 0.455 |
| HDL-chol (mmol/L) | 1.45 (1.05, 1.98) | 1.55 (1.02, 2.05) | 1.34 (1.07, 1.87) | 0.371 | 1.51 (1.16, 2.05) | 1.60 (1.14, 2.16) | 1.48 (1.16, 1.88) | 0.090 |
| LDL-chol (mmol/L) | 4.99 (3.91, 6.14) | 4.84 (3.73, 6.35) | 5.03 (4.25, 6.06) | 0.666 | 4.61 (3.50, 5.90) | 4.61 (3.58, 5.90) | 4.61 (3.14, 5.91) | 0.509 |
| PLA2R titer (RU/ml) | 280.61 (226.79, 360.18) | 280.61 (215.70, 356.63) | 281.44 (231.87, 370.74) | 0.705 | 59.02 (31.83, 95.10) | 61.35 (32.00, 99.92) | 52.10 (30.15, 92.18) | 0.439 |
Data were showed as median (25%–75% interquartile range). p value: CTX, subgroup vs. TAC subgroup. p-value <0.05 was considered statistically significant. CTX: cyclophosphamide; TAC: tacrolimus; SBP: systolic blood pressure; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate; TG: triglyceride; TCHO: total cholesterol; HDL-chol: high-density lipoprotein cholesterol; LDL-chol: low-density lipoprotein cholesterol; PLA2Rab: antibodies against the M-type phospholipase-A2-receptor.