TABLE 5.
The comparison of clinical parameters over time.
| Clinical parameters values | Percentage changes of clinical parameters values | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | Months | Overall cohort | High titer | Non-high titer | p-value | Overall cohort | High titer | Non-high titer | p-value |
| Up (g/24 h) | Baseline | 7.02 (4.60, 10.37) | 11.18 (9.51, 13.66) | 5.62 (4.33, 7.78) | <0.001 | — | — | — | — |
| 3 | 3.61 (3.01, 6.25) | 8.72 (6.51, 10.57) | 3.52 (2.27, 3.69) | <0.001 | −40.77 (−62.94, -20.87) | −23.82 (−39.06, −14.00) | −48.44 (−69.58, −25.53) | <0.001 | |
| 6 | 2.22 (0.68, 3.95) | 3.84 (2.94, 4.60) | 1.41 (0.46, 3.52) | <0.001 | −69.65 (−89.54, −53.78) | −65.10 (−77.09, −56.66) | −74.95 (−92.17, −49.73) | 0.016 | |
| 12 | 0.51 (0.20, 2.41) | 3.54 (0.55, 4.13) | 0.34 (0.15, 1.03) | <0.001 | −92.13 (−97.19, −71.99) | −71.29 (−95.05, −60.86) | −94.07 (−97.50, −83.20) | <0.001 | |
| Salb (g/L) | Baseline | 24.87 (20.67, 28.18) | 20.62 (18.20, 22.38) | 27.10 (23.10, 28.59) | <0.001 | — | — | — | — |
| 3 | 27.15 (22.56, 31.03) | 20.94 (20.01, 24.30) | 30.08 (25.61, 31.50) | <0.001 | 8.54 (3.61, 17.79) | 6.88 (0.46, 14.46) | 8.96 (4.32, 19.52) | 0.002 | |
| 6 | 32.74 (25.15, 36.12) | 24.13 (21.30, 30.60) | 34.03 (30.32, 37.30) | <0.001 | 25.88 (11.64, 44.01) | 19.71 (8.04, 39.25) | 27.21 (13.54, 46.01) | 0.016 | |
| 12 | 36.10 (31.75, 40.20) | 27.18 (21.04, 34.71) | 39.00 (34.81, 41.17) | <0.001 | 41.76 (23.43, 63.81) | 29.94 (6.70, 63.81) | 44.22 (30.79, 64.56) | 0.001 | |
| Scr (µmol/L) | Baseline | 77.89 (63.49, 96.49) | 82.20 (64.50, 99.13) | 77.44 (63.33, 93.54) | 0.186 | — | — | — | — |
| 3 | 67.70 (60.12, 80.57) | 69.57 (60.15, 82.50) | 66.50 (60.04, 80.45) | 0.329 | −11.54 (−19.04, −2.81) | −11.11 (−18.97, −2.42) | −11.89 (−19.16, −3.31) | 0.825 | |
| 6 | 65.48 (56.90, 75.69) | 68.59 (58.19, 78.30) | 64.30 (56.58, 75.46) | 0.212 | −13.95 (−23.84, −3.02) | −14.88 (−23.59, −5.08) | −13.40 (−24.39, −1.48) | 0.499 | |
| 12 | 66.13 (58.97, 77.13) | 66.32 (60.00, 78.25) | 65.97 (58.23, 76.22) | 0.351 | −14.52 (−23.49, −3.95) | −16.16 (−22.96, −4.54) | −14.09 (−23.62, −3.47) | 0.440 | |
| eGFR (ml/min/1.73 m2) | Baseline | 93.02 (74.83, 106.83) | 88.93 (75.22, 103.46) | 95.41 (73.72, 107.86) | 0.067 | — | — | — | — |
| 3 | 100.40 (87.40, 111.21) | 97.74 (84.73, 109.03) | 102.36 (87.69, 111.66) | 0.114 | 7.19 (1.14, 19.25) | 6.61 (−0.34, 21.52) | 7.25 (1.35, 18.08) | 0.971 | |
| 6 | 101.87 (91.10, 111.56) | 101.23 (88.26, 108.87) | 102.11 (92.08, 113.00) | 0.125 | 9.14 (0.78, 23.54) | 10.44 (1.60, 25.09) | 7.99 (0.54, 22.79) | 0.291 | |
| 12 | 102.36 (91.72, 111.09) | 101.03 (88.83, 109.68) | 102.65 (92.08, 111.59) | 0.153 | 9.39 (1.86, 23.91) | 11.00 (1.78, 25.40) | 8.53 (1.81, 23.44) | 0.460 | |
Data were showed as median (25%–75% interquartile range). p-value: high titer vs. non-high titer. p-value <0.05 was considered statistically significant. Up, urinary protein; Salb, serum albumin; Scr, serum creatinine; eGFR, estimated glomerular filtration rate.