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. 2022 Jan 17;12:780300. doi: 10.3389/fendo.2021.780300

Figure 4.

Figure 4

Adult female offspring of HFD dams display insulin resistance in normal chow diet. Body weight of females measured from 7-32 weeks of age (n=5, 8 ctrl and HFD offspring, A). Fasting body weight measured from 16-20 weeks of age (n=5, 9 Ctrl and HFD offspring, B). Random blood glucose of females measured at 22 and 28 weeks (n=5, 9 Ctrl and HFD offspring, C). Fasting blood glucose measured from 16-20 weeks of age (n=5 Ctrl and HFD offspring, D). IPGTT of females at 16-18 weeks old and AUC insert (n=9 Ctrl and HFD offspring, E). ITT of 20-week-old female and adjusted by % basal of glucose with AUC insert (n=4, 9 Ctrl and HFD offspring, F, G). In vivo GSIS of females at 22 weeks old (n=4 Ctrl and HFD offspring, H) and AUC insert. At least 3 litters per treatment were used (A–H). Statistical analysis was performed using two-way ANOVA Sidak’s multiple comparisons (A–H). No significant interaction effect was discovered. Significant treatment effects were indicated as *. Error bars represented ± SEM. *p < 0.05, **p < 0.01 Ctrl vs. HFD. Non-significance indicated as n.s.