Box plots of messenger RNA (mRNA) expression of thyroid iodide-handing genes in PTC. (A) Comparison of gene expression levels between BRAF V600E–negative and –positive groups by dividing entire cohort into 2 genotype groups. (B) Comparison of gene expression levels between TERT promoter mutation–negative and –positive groups by dividing entire cohort into 2 genotype groups. Central horizontal lines represent medians, and box boundaries represent interquartile ranges. Sample sizes in BRAF mutation–negative and –positive groups were 160 and 226, respectively. Sample sizes in TERT mutation–negative and –positive groups were 347 and 39, respectively. TERT promoter mutations here included, collectively, TERT C228T and TERT C250T. P values were calculated using 2-sided Wilcoxon–Mann–Whitney test.