TABLE 1.

Relationship Between BRAF V600E or TERT Promoter Mutations and Loss of RAI Avidity in Recurrent PTC

	Loss of RAI		Odds ratio
Tumor type and mutation status	n	P	Unadjusted	Adjusted*
All PTC
BRAF V600E
Negative	21/62 (33.9)		1.00	1.00
Positive	82/102 (80.4)	<0.001	7.88 (3.69–17.51)	7.11 (3.24–16.27)
TERT mutation
Negative	61/117 (52.1)		1.00	1.00
Positive	42/47 (89.4)	<0.001	7.63 (2.75–26.46)	6.89 (2.28–25.66)
CPTC
BRAF V600E
Negative	10/39 (25.6)		1.00	1.00
Positive	71/87 (81.6)	<0.001	12.52 (4.82–35.27)	10.78 (4.03–31.38)
TERT mutation
Negative	47/91 (51.6)		1.00	1.00
Positive	34/35 (97.1)	<0.001	31.23 (4.81–1,322.43)	31.37 (4.39–1,402.18)

^*Adjusted for patient age and sex.

CPTC = conventional PTC.

TERT promoter mutations here included, collectively, TERT C228T and TERT C250T. Data in parentheses are percentages or 95% CIs.