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Safe 211At-AITM dosage for normal C57BL/6J mice. (A) LD50 values of 211At-AITM. A dose-dependent study was performed by administering a single dose of 211At-AITM (0–7.4 MBq) to normal mice. All mice survived when a dose of less than 3.7 MBq 211At-AITM was administered via injection. (B) Changes in body weight. (C) Changes in leukocyte and platelet counts. Data are expressed as mean ± SD, respectively (n = 8). LD50 = lethal dose50.
