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18F-fluoroestradiol PET/CT images of a postmenopausal woman with invasive ductal carcinoma (ER-positive, PR-positive, HER2-negative) and histologically confirmed metastatic disease show uptake in a left supraclavicular lymph node that does not meet size criteria for anatomic enlargement (A, arrow) and retroperitoneal lymph nodes (B, arrow). Physiologic clearance is noted in small bowel.
