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. 2020 Feb;61(2):276–284. doi: 10.2967/jnumed.119.229567

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© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 3. — (A and B) PET frame reconstruction with ICA overlay (white) for early (A) and late (B) times after injection. Temporal and spatial variabilities of ICA background can be clearly deduced from images. (C) Tracer distribution in vicinity of ICA displays both radial and circumferential tracer concentration gradients. (D) Definition of subregions in vicinity of P_mask used to account for partial-volume distortions. BG_1, BG₂, and BG₃ = various background regions with homogeneous tracer concentrations; BS = brain activity; CA = measured activity in ICA; MZ = activity in MZ.