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. 2022 Jan 27;63(1):37. doi: 10.1167/iovs.63.1.37

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Figure 3. — Apoptosis of the retinal tissue in 17-day-old OIR mice. (A1–E3) Purple fluorescence indicates apoptotic cells. (A1–A3) TUNEL staining in the Control group. (B1–B3) TUNEL staining in the OIR group. (C1–C3) TUNEL staining in the OIR-C group. (D1–D3) TUNEL staining in the OIR-T (with Tug1 knockdown) group. (E1–E3) TUNEL staining of positive control cells. (F) Expression of BAX, Caspase-3, and Bcl-2, as determined with Western blotting, in the retinal tissues of the control, OIR, OIR-C, and OIR-T groups. (G) Number of apoptotic cells in each group (mean ± SD, n = 6). **P < 0.01 control versus OIR; **P < 0.01 OIR-C versus OIR-T. H. Relative expression levels of Bcl-2, BAX, and Caspase-3, normalized to β-tubulin levels. (mean ± SD, n = 6). *P < 0.05, **P < 0.01 control versus OIR; *P < 0.05, **P < 0.01 OIR-C versus OIR-T.