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. 2022 Jan 17;12:789730. doi: 10.3389/fphar.2021.789730

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Copyright © 2022 Klimovic, Scurek, Pesl, Beckerova, Jelinkova, Urban, Kabanov, Starek, Bebarova, Pribyl, Rotrekl and Brat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of arrhythmogenic effect of aminophylline on hPSC-CMs and HL-1 cells. R-R values over 3 s in case of hPSC-CM measurements or 1 s in case of HL-1 of aminophylline and control measurements were subtracted, and the resulting contingency tables were statistically analyzed. Column graphs show sums of cutoff R-R values (arrhythmic events) per 1,000 contractions in each treatment group and controls of (A) hPSC-CMs and (B) HL-1 experiments (chi-square test with Yates’ correction). Results show significant or partially significant higher frequency of aminophylline group cutoff values compared to that of the control. Poincaré plots of R-R values of representative concentration for (C) hPSC-CMs and (D) HL-1 experiments with visible cutoff lines.