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. 2022 Jan 17;12:793107. doi: 10.3389/fphar.2021.793107

FIGURE 2.

FIGURE 2

Therapeutic efficacy of aspirin against lung inflammation in mice (A) Gross appearance of the lungs from NF-κB-luciferase+/+ transgenic mice exposed to hyperoxia. Scale bar: 1 cm (B) Histological changes in the lungs of NF-κB-luciferase+/+ transgenic mice exposed to hyperoxia. Scale bars for the upper panel represent 200 µm and lower panel represent 50 µm (C) Lung-to-body weight ratio of NF-κB-luciferase+/+ transgenic mice exposed to hyperoxia. The values are reported as the means ± SEM (n = 6 mice per group). ## p < 0.01 compared with the N.C. group; *p < 0.05 and **p < 0.01 compared with the Mock group. N.C, treatment with PBS at 0, 24, and 48 h and exposure to normoxia; Mock, treatment with PBS at 0, 24, and 48 h and exposure to hyperoxia for 72 h; A25, treatment with 25 μg/g aspirin at 0, 24, and 48 h and exposure to hyperoxia for 72 h; A50, treatment with 50 μg/g aspirin at 0, 24, and 48 h and exposure to hyperoxia for 72 h. Arrow: red blood cells in the intra-alveolar space, consistent with hemorrhage. Triangle: intrapulmonary hemorrhage with some histiocyte aggregation.