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. 2022 Jan 26;18:101351. doi: 10.1016/j.tranon.2022.101351

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© 2022 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 2 — Knockdown/Overexpression of HNF1A-AS1 decreased/increased 5-FU resistance of GC cells. (A) Cell viability of MKN-45 cells transfected with sh-NC or sh-HNF1A-AS1 and treated with 5-FU for 24 h at the indicated concentrations detected by CCK-8 assay. (B) Cell viability of HGC-27 cells transfected with LV-NC or LV-HNF1A-AS1 and treated with 5-FU for 24 h at the indicated concentrations detected by CCK-8 assay. (C and D) Colony formation assay of MKN-45 cells transfected with sh-NC or sh-HNF1A-AS1 and pretreated with 5-FU. (E and F) Colony formation assay of HGC-27 cells transfected with LV-NC or LV-HNF1A-AS1 and pretreated with 5-FU. (G and H) Apoptosis rate of MKN-45 cells transfected with sh-NC or sh-HNF1A-AS1 and treated with 5-FU for 24 h detected by flow cytometry. (I and J) Apoptosis rate of HGC-27 cells transfected with LV-NC or LV-HNF1A-AS1 and treated with 5-FU for 24 h detected by flow cytometry. Data were presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.