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. 2021 Dec 31;30(1):72–90. doi: 10.1016/j.jsps.2021.12.009

Fig. 11.

Fig. 11

Effect of Diac and/or 5-FU for 7 weeks on protein content of (a) p-Akt, (b) GSK3-β and gene expression of (c) Nur77 in DMH-induced CRC rats. Data are expressed as means ± SD (n = 6 animals/group). Statistical analysis was carried out using one-way ANOVA followed by Tukey’s Multiple Comparison test; P < 0.05. As compared with (*) CONT, (#) CRC, (@) 5-FU and (ϕ) Diac-treated groups. Treatments started on week 16 after DMH administration and lasted for 7 weeks, where Diac was gavaged daily and 5-FU was injected once weekly. ANOVA: analysis of variance; CONT: control; CRC: colorectal cancer; Diac: Diacerein; 5-FU: 5-fluorouracil; GSK3-β: glycogen synthase kinase 3-β; p-Akt: phosphorylated protein kinase B.