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. 2022 Jan 14;57:101437. doi: 10.1016/j.molmet.2022.101437

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Adipocyte-specific knockout of Nos2 increases oxygen consumtion in HFHS-fed mice. Oxygen consumption (A), respiratory exchange ratio (B), total ambulatory movement (C) and carbon dioxide production (D) were measured by indirect calorimetry. Two-way ANOVA with a Student-Newman-Keuls post hoc test was applied to calculate the significance of the differences between groups. Data are expressed as the mean ± SEM. n = 9–12 (A,F), n = 5–6 (B,C), n = 10–12 (D,E). ∗p < 0.05 and ∗∗∗p < 0.001 for diet effect; ^#p < 0.05 and ^##p < 0.01 for genotype difference.