Skip to main content
. 2022 Jan 14;57:101437. doi: 10.1016/j.molmet.2022.101437

Figure 6.

Figure 6

Adipocyte-specific knockout of Nos2 increases BAT activation in HFHS-fed mice. BAT mRNA expression of genes related to energy metabolism: uncoupling protein 1 (Ucp1), uncoupling protein 2 (Ucp2), peroxisome proliferator-activated receptor alpha (Ppara), type 2 iodothyronine deiodinase (Dio2), G-coupled protein receptor (Tgr5) and peroxisome proliferator-activated receptor-gamma coactivator (Ppargc1a) (A). Protein expression of total OXPHOS complexes (B) and complexes I-IV (C) in BAT. BAT mRNA expression of genes related to lipid metabolism: Lipoprotein lipase (Lpl) and Fasting-induced adipose factor/Angiopoietin-like 4 (Angptl4) (D). Two-way ANOVA with a Student-Newman-Keuls post hoc test was applied to calculate the significance of the differences between groups. Data are expressed as mean ± SEM. n = 9–12. ∗p < 0.05, ∗∗p < 0.01 and ∗∗∗p < 0.001 for diet effect; #p < 0.05, ##p < 0.01 and ##p < 0.001 for genotype difference.