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. 2022 Jan 31;63:98–107. doi: 10.1016/j.cytogfr.2022.01.007

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Fig. 2 — ACE2: a bridge between gut and lung. (a) In the lung and gut, SARS-CoV-2 binds to the ACE2 and activates renin–angiotensin system (RAS) and kinin-releasing enzyme kinin system (KKS). (b) After tryptophan intake, ACE2 binds to B⁰AT1 to produce antimicrobial peptides via the mTOR pathway in the gut, which may be mediated by SARS-CoV-2 infection.