TABLE 3.

univariate cox and multivariate cox regression analyses.

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
TCGA PRAD cohort
Age (>60 vs. ≤60)	5.28 (3.48–6.86)	<0.001	4.69 (2.36–5.47)	<0.001
Race (Black or African American vs. Asian)	1.74 (0.254–5.84)	0.951	—	—
Riskscore (High vs. Low)	2.29 (1.63–3.65)	<0.001	1.67 (1.23–2.79)	<0.001
T (T1,T2vs. T3,T4)	0.37 (0.18–0.65)	0.041	0.46 (0.24–1.65)	0.21
N(N0vs.N1)	0.62 (0.42–0.81)	0.032	0.72 (0.54–0.89)	0.042
M(M0vs.M1)	0.76 (0.51–1.21)	0.63	—	—
Independent validation cohort
Age (>60 vs<=60)	4.81 (2.96–5.91)	<0.001	3.51 (2.19–5.78)	0.025
T (T2vs. T3,T4)	0.77 (0.59–0.89)	0.03	0.82 (0.53–0.98)	0.046
N (N0vs.N1)	0.68 (0.31–0.87)	0.02	0.63 (0.25–0.86)	0.031
M (M0vs.M1)	0.87 (0.36–1.86)	0.75	—	—
Riskscore (High vs. Low)	1.87 (1.36–2.05)	<0.001	1.42 (1.14–1.75)	0.034